Diabetes mellitus type 2, formerly called adult-onset diabetes, is a type of diabetes, which is characterized by high blood sugar (hyperglycemia), insulin resistance shown by the body cells, and later a relative lack of insulin.
There is no permanent cure for this condition. However, staying at an ideal weight, eating healthy, and exercising regularly can help you manage the disease. If diet and exercise do not control your blood sugar, you may also need diabetes medications
It is caused due to the failure of the body cells to take up glucose from the blood. Your pancreas may produce adequate insulin, but the body cells do not utilize the glucose in the blood.
This is due to the failure of insulin, which normally makes the uptake of glucose by the body cells possible.
That is the reason the glucose in the blood is not utilized or is underutilized and its level in the blood rises above the normally permissible limit. That is when you start showing symptoms of diabetes and your doctor then pronounces you a diabetic.
The treatment of type 2 diabetes, therefore, involves increasing the sensitivity of the body cells so that they take up the glucose from the blood and utilize it for energy.
There are two important things you can do to manage your :
- Exercise daily to burn the extra glucose in the blood and
- Secondly, have a healthy diabetes-friendly diet.
Even without medication, it is possible to control your blood sugar and treat your mild to moderate diabetes if you follow the above two guidelines religiously.
But, most of the time diabetes drugs become necessary. What the doctor will do to treat you is give you advice and put you on the best line of medication that suits you.
Usually, the first line of treatment for type 2 diabetes is oral medications. Sometimes, these diabetes pills may not control the blood sugar and the doctor may then prescribe insulin injections.
Exercise is very important to treat and manage diabetes type 2
Exercise benefits on the health of the diabetic are as significant as sticking to the diabetes diet plan. Both these factors help in lowering the doses of your diabetes medicines. In fact, studies have shown these two factors can well reverse diabetes type 2 and help you stop your diabetes medication.
Exercise, especially aerobic exercises is necessary for a diabetic because it controls the weight and lowers the blood sugar level by improving insulin sensitivity. It also gives a sense of well-being and an overall better feeling.
When you exercise, the body utilizes the glucose in the blood and converts it into energy required for physical activity. The fall in the blood glucose levels relaxes the beta cells in the pancreas and they stop producing insulin. Please note that exercise does not cause the blood sugar to fall below normal levels in a healthy person.
About 30 to 60 minutes into your exercise activity, your body starts utilizing the fat cells in the fat depots for energy. You thereby not only lower your blood glucose levels but also burn the fat, helping in weight loss.
Diabetes-friendly diet plan
In diabetes type 1 or type 2, eating the right foods and having the right diabetes-friendly diet plan is as important as diabetes medication.
Otherwise, your treatment will just not be as effective. Knowing what foods to eat and what foods not to eat in diabetes, therefore, is of paramount importance in the management of diabetes. Furthermore, the diabetes diet menu does not put too many restrictions and you should have no problems adhering to it.
It is a healthy eating plan, which gives you the right amount of nutrients and stays low on fats and calories. It is a low-carb diet, which improves your blood sugar levels, helps in weight loss, and is also good for heart health
Monitoring your blood sugar at home
The primary aim of diabetes treatment is to keep blood sugar levels within normal limits.
Measuring blood sugar levels forms an important part of your diabetes care program. How else will you know if your treatment is working? You and more importantly your doctor can know this only if you keep checking your sugar levels and forwarding the reports to your doctor.
Treating diabetes initially often requires a little trial and error method to figure out the best and the safest oral medication for you along with the optimum doses that will keep your diabetes under control.
Testing for diabetes can be done at home using a glucometer.
How often should test your blood sugar levels for diabetes type 2?
The frequency of testing your blood sugar levels depends largely on the type of medication you are taking. If you are on insulin injections, you will have to check at least twice a day. Testing is usually recommended before taking meals and at bedtime.
If you are managing your diabetes with other oral pills, exercise, and diet, you may not have to test daily, once it is known that your diabetes is stabilized.
What should be your blood sugar target range?
Your doctor will fix the target range of your blood sugar. It will depend on several factors:
- Your age
- Duration of diabetes
- Whether you have any diabetes complications
- Whether you have any other associated health conditions such as high blood pressure, increased cholesterol and heart disease
- Whether you are pregnant or not
According to diabetes.co.uk, The National Institute for Health Care Excellence (NICE) guidelines recommend the levels for type 2 diabetes in adults as follows:
- Before meals (fasting): 4 to 7 mmol/ or 72 mg/dl to 123 mg/dl
- After meals (2 hours postprandial) under 9 mmol/L or under 162 mg/dl
Diabetes type 2 prescription oral medications
Type 2 diabetes requires oral drugs for treatment unlike type 1 diabetes, which has to be treated with injectable insulin only.
There are various oral prescription medications and each has its indications. However, it is seen in some cases that oral drugs do not succeed in controlling blood sugar. In such cases, the doctor may additionally put the patient on injectable insulin therapy.
Below is the list of oral prescription medicines to treat diabetes type 2. I have also mentioned the generic and the brand names for easy identification.
Brand names: Glucophage, Glumetza, and others
Generic name: Metformin HCL
Metformin oral pills are the first line of medication prescribed in diabetes type 2 treatment. It lowers blood sugar by increasing the sensitivity of your body tissues to insulin. This helps the uptake of blood sugar by the body tissue cells, thereby lowering the increased blood sugar levels.
In a diabetic, who religiously follows the diabetic diet and performs a regular physical activity, metformin also reduces glucose production by the liver.
Dosage: Metformin is a biguanide that comes in a tablet form of 500 mg and 850 mg in strength. It is available as an immediate-release form or extended-release form.
Immediate release metformin (eg Glucophage) is initially started in the dose of 500 mg twice a day or 850 mg once a day.
The dose is increased by 500 mg every two weeks according to tolerance. The maintenance dose is 2000 mg per day in divided doses. If required, your doctor may increase this dose but not beyond 2500 mg per day.
Extended-release metformin tablets (eg Glucophage XR) are initially started with a dose of 500 to 1000 mg once a day and gradually increased by 500 mg weekly to a maintenance dose of 2000 mg per day. The maximum permissible dose is 2500 mg per day. If necessary, it can be given in divided doses.
Side effects of metformin include nausea, vomiting, stomach upset, diarrhea, weakness, or you may develop a metallic taste in the mouth. That is why metformin is advised to be taken with meals.
Side effects disappear once you get used to this drug. However, if they persist or worsen, your doctor may reluctantly put you on another drug though metformin is the best and safest drug for diabetes type 2.
Brand names: Diabenese, Glyburide, Glipizide, Glimepiride
Generic name: Chlorpropamide
There are several types of sulphonylureas medicines and they all act by stimulating the beta cells of the pancreas to secrete more insulin and lower blood sugar.
Diabenese is the first generation drug still in use today. The second-generation sulphonylureas used are glipizide (Glucotrol and Glucotrol XL), glyburide (Micronase, Glynase, and Diabeta), and Glimepiride (Amaryl).
The advantage of second-generation sulphonylureas is that they are required to be taken in smaller doses.
These medicines are used as replacement therapy when the patient cannot tolerate metformin and when you are not overweight. They are also given with metformin if metformin cannot control blood sugar on its own.
Sulphonylureas tablets are taken once or twice a day with meals.
- Starting: 1 – 2 mg once daily
- Maintenance: 2 – 8 mg once daily
- Max: 8 mg once daily
Side effects include low blood glucose, skin rash, irritability, upset stomach, and weight gain. Due to its side effect of lowering blood glucose, a diabetic patient on this drug should always carry some source of sugary food with him.
Brand names: Starlix, Prandin
Generic names: Nateglinide, Repaglinide,
Meglitinides act in the same way as sulphonylureas by stimulating the pancreas to secrete more insulin. However, their mode of action is faster but shorter. Due to this mode of action of stimulating the pancreas, they may cause hypoglycemia (low blood sugar level). Weight gain is another possible side effect. Their side effects do not last very long.
They are not commonly used but may not be advised if your meal timing is irregular. They are advised three times a day before meals.
Brand names: Actos, Avandia
Generic names: pioglitazone, rosiglitazone
The mode of action of thiazolidinediones is similar to that of metformin. They increase the sensitivity of the body tissues to insulin thereby facilitating the uptake of glucose from the blood.
They also reduce the production of glucose in the liver.
Side effects include weight gain, increased risk of heart failure, swelling of the ankles, and fractures. People on these drugs are closely monitored for liver damage.
Thiazolidinediones are commonly advised to be taken with metformin, sulphonylureas, or both. Tablets with such combinations are available.
Thiazolidinediones are used when other medications fail to lower the blood glucose within the target range.
5. Selective Dipeptidyl Peptidase-4 Inhibitors (DPP-4 inhibitors)
Brand Names: Nesina, Tradjenta, Onglyza, Januvia
Generic Names: alogliptin, linagliptin, saxagliptin, sitagliptin
These drugs have the most powerful effect of lowering blood sugar. They are available in combination with other oral diabetes medicines. They do not cause weight gain.
Mode of action: Incretin is a naturally occurring hormone in the body that stimulates the pancreas to release insulin after you eat. An enzyme called dipeptidyl peptidase-4 (DPP-4) removes it from your body. This is a normal process in healthy people.
Some people with diabetes type 2 do not produce adequate insulin. DPP-4 inhibitors inhibit the action of DPP-4. This helps incretin to stay in the body longer and stimulate longer insulin production.
6. GLP-1 receptor agonists
This medication is not used alone. It is used in combination with metformin plus sulphonylureas.
It is injected twice a day and lowers raised blood glucose levels, without the risk of hypoglycemia.
It has the added advantage of causing weight loss and is therefore preferred in obese people.
7. SGLT2 inhibitors
Sodium-Glucose Transporter 2 (SGLT2) Inhibitors are the latest diabetes drugs on the market. They prevent the kidneys from absorbing sugar and instead they are excreted through the urine.
Side effects include yeast infection, urinary tract infection, and penile foreskin infection in men. These side effects are due to increased sugar in the urine. It is not advised in elderly people with kidney disease and in people who are taking diuretics for fear of dehydration.
Examples are canagliflozin (Invokana) and dapagliflozin (Farxiga).
Insulin therapy for diabetes type 2
Most diabetics have a fear of being put on insulin therapy. The very idea of taking insulin shots daily is not welcome. Oral insulin does not work because the digestive juices in the stomach break it down. Insulin injection or insulin pen or an insulin pump are used.
However, diabetes is a progressive disease and at times, it becomes necessary to start insulin to compensate for the decline in insulin production by the pancreas.
If you are not following your doctor’s prescription religiously, you do not exercise, and do not stick to the diabetes meal every day, your A1C is bound to go high. Your doctor will then put you on insulin treatment with the aim to bring your A1C to or below 7 percent.
At times, this may be only for a short period to control your blood sugar level. Insulin may also be given along with other oral diabetes medicines such as metformin (Glucophage).
Insulin is recommended when the A1C is initially above 9 percent or when oral diabetes medicines do not control your blood sugar.
Side effects of insulin injections include:
- Pain due to insulin injections
- Frequent blood sugar monitoring
- Weight gain due to the anabolic nature of insulin and
- Hypoglycemia is due to the mismatch between food (carbohydrates) intake, exercise, and alcohol consumption.